清流整形美容論壇

[plasticsuper]

很多皮膚科醫師都會告誡病人：吃A酸期間傷口修護有問題不宜手術。

不過最近也有不少醫師對此提出質疑，因為A酸影響傷口癒合的實驗是在實驗室做的並非直接人體測量的結果。以下這篇文章搜尋所有有關A酸和組織修復的文章整理出一個結論，值得了解。

出處：Aesthetic Plastic Surgery 2016, 40(1):139-148

摘要：
Background
Oral isotretinoin is increasingly being used to treat acne and other dermatological conditions. The number of patients who take isotretinoin and wish or need to undergo plastic surgery may be following a similar pattern. Although skin healing is an important concern in the case of patients who use isotretinoin, it is definitely not the only relevant issue when planning surgical intervention.
Methods
Eleven important points regarding surgery safety in patients taking oral isotretinoin were defined. A literature search of the PubMed database was conducted by employing the keywords isotretinoin OR 13-cis-retinoic acid. This returned the largest possible number of studies about isotretinoin.
Results
Forty-seven studies matched the selection criteria. Most animal experimental models suggested that isotretinoin at doses commonly used to treat acne is not detrimental to wound healing. Human studies are controversial. However, healing of skeletal muscle could be at increased risk of necrosis.
Conclusions
Association between isotretinoin and problematic skin healing after surgery is being challenged. Also, recommended time between discontinuation of isotretinoin and surgery should be reviewed. While muscle flaps may be endangered in patients taking isotretinoin, healing of other tissues and systemic effects that could compromise surgery safety are rare or detectable before surgery.

作者搜尋了所有A酸和皮膚、軟骨、骨骼、肌肉、肝腎心、及感染相關的文章。結論是治療青春痘的A酸濃度下除了肌肉以外，其它的器官沒有明顯證據證明有害。

不過，我要提醒大家，這篇研究也不是向大家保證A酸對皮膚什麼的完全無害，只是說現有的研究不足以證明有害而已。